According to various authors, 30-40 % of the population of our planet suffer from dyspeptic frustrations, such as feeling of overflow in epigastria, early saturation, a swelling of a stomach, a nausea, vomiting, an eructation, a pain or sensation of discomfort in epigastric area, which are connected and not connected with reception of food. The most frequent reason of occurrence of these complaints is diseases of the top departments of gastroenteric path, such as gastroesophagal reflux disease, functional (not ulcer) disperse, primary or secondary gastroparesis, a stomach ulcer.

In a basis of these frustration infringements of a motility of a stomach and thin intestines, and also oburator activity of esophageal-gastric and gastroduodenal sphincter lay.

Burden in a stomach, feeling of overflow in epigastric areas, early saturation - set of shades of one of frequent displays of diseases of a stomach. Burden in a stomach is often combined with nausea, a swelling of a stomach, heartburn, dull pains in epigastric areas. More often these complaints are caused by infringements of motor function of the stomach, causing unpleasant or painful feelings in the top departments of a stomach which, in turn, stir daily activity, limit a feed, movement, rest, physical activity, and worsen quality of life of patients. According to statistics up to 45 % of inhabitants of our planet irrespective of their social status and a financial position test burden in a stomach, however only 20-25 % of patients address for medical aid, preferring to follow recommendations of the pharmacist.

The problem of unpleasant sensations in a stomach (burden, sensation of overflow, a nausea) are very widespread. In opinion of some scientists, the third of people feel discomfort in a stomach more often, than once a month, and everyone the fifth - every week. The reason of burden in a stomach is infringement of normal work of a stomach.

The stomach of the person is a motor of process of digestion of food. Normally, the food mixes up in a stomach till 4 o'clock. Work of a stomach can be broken owing to stresses, mistakes in a diet, a dry feed, thus the stomach stops, the food stands. Feeling of burden, overflow, a nausea appear.

The ferment preparations are intended for splitting food in intestines, therefore they operate in the alkaline environment (normal for intestines). The sour environment of a stomach destroys them, as all enzymes are albumens by their chemical nature. Therefore all ferment preparations are covered by special protective acidproof (intestinally-soluble) environment owing to what operate only in intestines.

The normal motility of a stomach is provided by coordinated work of a muscular layer, thus there is a crushing peep, its hashing with gastric juice and promotion in the distal direction. The propulsive activity of a stomach and the condition of sphincters are adjusted by vegetative nervous system, and also by the hormones of a digestive path. Infringement of nervous regulation of a stomach, and also of humoral factors leads to infringement of the correct coordinated work of a muscular layer and sphincters. Thus hyper- or hypotonia of a stomach develops. There are such infringements of motility, as delay of moving of contents or retrograde movement of contents (refluxes). Delay of moving of a content of a stomach in a distal direction also causes occurrence of complaints on burden in a stomach, sensation of overflow in epigastric areas, early saturation.

Application of prokinetics is approved by Considering mechanisms of occurrence of such symptoms as burden in a stomach, sensation of overflow in epigastric area, early saturation, with the purpose of improvement of a motility of a stomach and elimination of the specified displays.. One of the most effective and safe of them today is MOTILIUM.

Motilium quickly normalizes the work of a stomach, launches the stomach with new force. Motilium helps a stomach to mix food and to push it in intestines. Motilium quickly and effectively helps to get rid of burden in a stomach, feelings of overflow, and nausea.

Motilium is the fast aid to a stomach!

Pharmacodynamic effects of "Motilium" are connected with its blocking influence on peripheral dopamine receptors which have been found out in a wall of a stomach and a duodenal gut, and consist in strengthening of a tone and peristaltic activity of mainly top departments of a digestive path. " Motilium " strengthens the peristaltics of a gullet and the tone of its bottom sphincter. It raises (restores) the retroactive ability of a stomach and interferes with its relaxation that leads to improvement of evacuation from a stomach. The specified action begins already 15 minutes after the reception of a preparation and is demonstrated both in liquid and firm food.

Motilium is widespread in treatment of gastroparesis at the patients suffering from diabetes, scleroderma systematica after surgical operations on stomach with an application of vagotomy.

Thus, MOTILIUM:

• effectively normalizes the impellent function of a stomach, restores a natural rhythm of its work;
• operates quickly;
• possesses a favorable structure of safety.

It is confirmed both by the results of clinical researches and experience of doctors.

Description

Domperidone(dom-PER-i-done) is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Domperidone is to be given only by or under the immediate supervision of your doctor. It is available in the following dosage forms:

Before Receiving This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For domperidone the following should be considered:

AllergiesTell your doctor if you have ever had any unusual or allergic reaction to domperidone.

PregnancyPregnancydomperidone has not been studied in pregnant women. However, domperidone has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding Breast-feedingDomperidone passes into the breast milk, but it is not known if domperidone will cause unwanted effects in the newborn. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.

ChildrenChildrenStudies on this medicine have been done only in adult patients, and there is no specific information comparing use of domperidone in children with use in other age groups.

Older adultsMany medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of domperidone in the elderly with use in other age groups.

Other medicinesAlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your doctor or pharmacist if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine, especially:

• Monoamine oxidase (MAO) inhibitors (furazolidone [e.g., Furoxone], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegilene [e.g., Eldepryl], tranylcypromine [e.g., Parnate])

Other medical problemsThe presence of other medical problems may affect the use of domperidone. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding from the stomach or other problems involving the bowels
• Pituitary (brain) tumor
• Liver disease
• Medicine sensitivity to domperidone

Proper Use of This Medicine

DosingThe dose of domperidone will be different for different patients.Follow your doctor's orders or the directions on the label. The following information includes only the average doses of domperidone.If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets of that you take depends on the strength of the medicine. Also,the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking domperidone.

• Fororal dosage form (tablets):
• Treatment of gastrointestinal motility disorders:
• Adults10 milligrams (mg) three to four times daily. Some patients may require higher doses up to 20 mg three or four times daily.
• Nausea and vomiting:
• Adults20 milligrams (mg) three to four times daily.

Missed doseIf you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

StorageTo store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur

Difficulty in speaking; disorientation; dizziness; fainting; irregular heartbeat; light-headedness ; loss of balance or muscle control

Check with your doctor immediately if any of the following side effects occur:

Less common

Loss of balance or muscle control; swelling of the mouth

Rare

Fast, irregular, pounding, or racing heartbeat or pulse; swelling of face, hands, lower legs, or feet

. Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

Less common

Breast milk flowing from the nipple; dry mouth; swelling of the breast in the male; headache; hives; hot flashes; itching of skin; itching, redness, pain, or swelling of eye; menstrual irregularities; pain in the breast

Rare

Change in need to urinate; change in appetite; constipation; diarrhea; burning, difficult, or painful urination ; difficulty in speaking ; dizziness; drowsiness; heartburn; irritability; lack or loss of strength; leg cramps; mental dullness; nervousness; palpitations; sluggishness; stomach cramps; thirst; tiredness; weakness

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.