Etoricoxib (Arcoxia brand worldwide and Algix and Tauxib in Italy) is a new selective COX-2 inhibitors (about 106.0 times more selective COX-2 inhibition of COX-1) with Merck & Co. dose of 60, 90 mg / day for chronic pain and 120 mg / day in acute pain. At the present time it is approved in more than 60 countries around the world, but not in the U.S., where food and drugs (FDA) require additional safety and efficacy data for etoricoxib Before granting the approval. Current therapeutic indications: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic back pain, acute pain and gout. Please note that the approved indications vary from country to country.

As with any other selective COX-2 inhibitors selectively inhibits etoricoxib isoform 2 of cyclo-oxigenase enzyme (COX-2). This reduces the generation of prostaglandins (PG's) from arachidonic acid. Among the various functions attached PGs, their role in the inflammation cascade should be. Selective COX-2 inhibitors (aka COXIB ") shows marked by type of activity is less than 1 cycloxigenase compared with traditional non-steroidal anti-inflammatory drugs (NSAIDs). This led to a decline in activity is the cause of reducing the toxicity of the gastro-intestinal tract, as in several large clinical studies with different COXIB (see below links to NEJM and The Lancet).

Several clinical studies and meta-analysis showed that treatment with COXIB led to an increase in adverse cardiovascular events compared to placebo. From these results, some molecules from the trade (rofecoxib, in September 2004 and valdecoxib, in April 2005). In addition, FDA and the EMEA (European Community and U.S. health authorities, respectively) began the process of reviewing an entire class, so that NSAIDs and COX-2 inhibitors.

What is the shelf life of the pills?

• The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.